New Directions in Soft-Tissue Sarcomas Other Than GIST: A Focus on Sarcoma Centers

This activity contains:

  • CME/CPE/CNE-Certified Live Grand Rounds
  • ​Downloadable Slide Deck with Speaker Notes (a non-certified educational resource)
  • Toolkit (a non-certified educational resource that contains a Pocket guide, an Information therapy Rx pad, and a patient log template)

The goal of this activity is to provide clinicians with in-depth information about the latest approaches to the treatment of soft-tissue sarcomas other than GIST

Course Overview
The management of soft-tissue sarcomas has been challenging because the traditional therapies are generally associated with low response rates or high toxicity rates. However, new and emerging therapies are providing more promising options. To provide patients with the best possible care, clinicians in sarcoma specialty centers must be able to incorporate a strong knowledge of these therapies into treatment considerations and discussions with patients and families.

This Grand Rounds initiative is designed to provide clinicians with the latest information about the treatment of non-GIST soft-tissue sarcomas. Topics covered in this activity include the safety and efficacy of new therapies, assessing the response to treatment, and strategies for talking with patients and their families about this disease and its treatment.

Target Audience

This activity is intended for surgical, orthopedic, and medical oncologists; radiologists; pathologists; oncology nurses and pharmacists who may evaluate or treat patients with soft-tissue sarcomas.

Learning Objectives

At the conclusion of this activity, participants should be better able to:

  • Utilize a strong knowledge of the risks and benefits of standard, new, and emerging therapies for soft-tissue sarcomas other than GIST when discussing treatment options with patients and their families
  • Assess tumor response to treatment, recurrence, and drug-related toxicities in patients being treated for soft-tissue sarcomas
  • Engage patients and their families in treatment decision making, to arrive at the optimal treatment choice based on the patient’s preferences, the current standard of care, and emerging therapies
  • Use shared decision-making practice to optimize therapy, treatment adherence, and patient satisfaction in patients with soft-tissue sarcomas


  • Activity Overview (5 min) 
  • Review of Unresectable, Advanced Soft-Tissue Sarcomas Other Than GIST (5 min)
  • New and Emerging Systemic Therapies (15 min)
  • Specialty Sarcoma Care Team Considerations (5 min)
  • Interactive Case Discussion #1: Systemic therapy considerations, based on disease and patient-related factors (8 min)
  • Interactive Case Discussion #2: A challenging clinical scenario (8 min) 
  • Interactive Case Discussion #3: Using shared decision-making approach to treatment decisions (8 min)
  • Conclusions; review and distribution of toolkit and online link (5 min)
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 ACPE
  • 1.00 ANCC
Course opens: 
Course expires: 


George D. Demetri, MD
Professor of Medicine
Harvard Medical School
Director, Ludwig Center at Harvard
Senior Vice President for Experimental Therapeutics
Dana-Farber Cancer Institute
Associate Director for Clinical Sciences
Boston, Massachusetts



Andrew S. Brohl, MD
Medical Oncologist
Sarcoma Department
H. Lee Moffitt Cancer Center & Research Institute
Tampa, Florida

Kristen N. Ganjoo, MD
Associate Professor of Medicine (Oncology)
Stanford University Medical Center
Stanford, California

Scott H. Okuno, MD
Professor of Oncology
Sarcoma Tumor Chairperson
Mayo Clinic – Rochester
Rochester, Minnesota

Raphael E. Pollock, MD, PhD, FACS
Professor and Director, Division of Surgical Oncology
The Ohio State University Wexner Medical Center
Surgeon in Chief
James Comprehensive Cancer Center
The Ohio State University Health System

Richard F. Riedel, MD
Associate Professor of Medicine
Associate Director, Clinical and Translational Research, Duke Sarcoma Program    
Duke Cancer Institute
Duke University Health System
Durham, North Carolina

Gary K. Schwartz, MD
Professor of Medicine
Columbia University College of Physicians and Surgeons
Chief, Division of Hematology and Oncology
Associate Director
Herbert Irving Comprehensive Cancer Center
New York, New York

Jonathan C. Trent, MD, PhD
Professor of Medicine
Director Musculoskeletal Center
Sarcoma Medical Research Program
University of Miami Miller School of Medicine
Associate Director for Clinical Research
Sylvester Comprehensive Cancer Center
Miami, Florida

Brian A. Van Tine, MD, PhD
Assistant Professor of Medicine
Sarcoma Program Director
Washington University
Saint Louis, Missouri

Margaret von Mehren, MD
Director, Sarcoma Oncology Program
Associate Director, Clinical Research
Professor, Medical Oncology
Fox Chase Cancer Center
Philadelphia, Pennsylvania

Continuing Medical Education

Accreditation Statement
In support of improving patient care, AXIS Medical Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Designation for Physicians
AXIS Medical Education designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Credit Designation for Pharmacists
This application-based activity is approved for 1.0 contact hour of continuing pharmacy education credit. UAN 0592-0000-16-015-L01-P.

Credit Designation for Nursing
AXIS Medical Education designates this continuing nursing education activity for 1.0 contact hour.

Learners are advised that accredited status does not imply endorsement by the provider or ANCC of any commercial products displayed in conjunction with an activity.

California Board of Registered Nursing
AXIS is approved by the California Board of Registered Nursing, Provider Number 16702, for 1.0 contact hour.

Iowa Board of Nursing
AXIS is Iowa Board of Nursing Approved Provider Number 371, for 1.0 contact hour. 

Disclosure of Conflicts of Interest
AXIS Medical Education requires instructors, planners, managers and other individuals and their spouse/life partner who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by AXIS for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. 

AXIS will identify, review, and resolve all conflicts of interest that faculty, authors, activity directors, planners, managers, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for speakers, authors, course directors, planners, peer reviewers, and/or relevant staff is provided with this activity. 

The faculty reported the following financial relationships or relationships they or their spouse/life partner have with commercial interests related to the content of this continuing education activity:

Name of Faculty or PresenterReported Financial Relationship
George D. Demetri, MDConsultant: Bessor Pharmaceuticals Corporation; Consultant, consulting fees: Adaptimmune LLC, Daiichi Sankyo Company, Ltd., EMD Serono, Inc., Genocea Biosciences, Janssen Oncology, Kymab Limited, Nektar Therapeutics, Novartis Pharmaceuticals Corporation, Pfizer, Inc., Pharma Mar, S.A., Polaris Pharmaceuticals, Sanofi Oncology, WIRB-Copernicus Group, Inc., ZIOPHARM Oncology, Inc.; Consultant, scientific advisory board: Caris Life Sciences, Inc., Champions Oncology, Inc., G1 Therapeutics, Kolltan Pharmaceuticals, Inc.; Consulting fees and equity (minor stake, non-public): Champions Oncology, Inc., G1 Therapeutics, Kolltan Pharmaceuticals, Inc.; Consulting fees and equity (minor stake, public): Blueprint Medicines;  Caris Life Sciences, Inc.; Equity (minor stake, non-public): Bessor Pharmaceuticals Corporation; Member, board of directors: Blueprint Medicines; Member, scientific advisory board: Blueprint Medicines; Patent licensed to Novartis from Dana-Farber with royalty paid to Dana-Farber: Novartis Pharmaceuticals Corporation; Research support to Dana-Farber for GD and PI: Bayer Pharmaceuticals Corporation, Janssen Oncology, Novartis Pharmaceuticals Corporation, Pfizer, Inc.
Andrew S. Brohl, MDServe(d) as a director, officer, partner, employee, advisor, consultant, or trustee for: GlaxoSmithKline (Spouse).
Kristen Ganjoo, MDAdvisory board: EMD Serono, Inc., Novartis Pharmaceuticals Corporation.
Scott H. Okuno, MDNo real or apparent conflicts of interest to report.
Raphael E. Pollock, MD, PhD, FACSNo real or apparent conflicts of interest to report.
Richard F. Riedel, MDContracted research: Bayer Pharmaceuticals Corporation, Eisai Inc., Eli Lilly and Company, Merck & Co., Inc., Novartis Pharmaceuticals Corporation, Plexxikon, Threshold Phrmaceuticals, TRACON Pharmaceuticals, Inc.; Data and safety monitoring board member: CytRx Corporation, Morphotek, Inc.; Ownership interest: BioTech Prosthetics & Orthotics of Durham (Spouse), Limbguard, LLC (Spouse).
Gary K. Schwartz, MDResearch grant: Astex Pharmaceuticals an Otsuka Pharmaceutical company.
Jonathan C. Trent, MD, PhDContracted research: Janssen Pharmaceuticals, Inc., Morphotek, Inc., Plexxikon; Serve(d) as a speaker or a member of a speakers bureau for: Janssen Pharmaceuticals, Inc
Brian A. Van Tine, MD, PhDServe(d) as a director, officer, partner, employee, advisor, consultant, or trustee for: Adventis, Eli Lilly and Company, GlaxoSmithKline, Janssen of J&J, Karyopharm Therapeutics Inc., Merck Serano, Novartis Pharmaceuticals Corporation; Serve(d) as a speaker or a member of a speakers bureau for: Caris Dx, Janssen of J&J, Novartis Pharmaceuticals Corporation.
Margaret von Mehren, MDServe(d) as a director, officer, partner, employee, advisor, consultant, or trustee for: Bayer Pharmaceuticals Corporation, CytRx Corporation, Janssen Pharmaceuticals, Inc.

The planners and managers reported the following financial relationships or relationships they or their spouse/life partner have with commercial interests related to the content of this continuing education activity:

The following AXIS planners and managers, Linda-Gracie-King, MS; Ronald Viggiani, MD; Isabelle Vacher; Sarah Williams, PhD; Jocelyn Timko, BS; Stephanie Sutphin, PharmD; Marilyn Haas, PhD, RN, CNS, ANP-BC; and Bert Thomas, PhD, MBA state that they or their spouse/life partner do not have any financial relationships or relationships to products or devices with any commercial interest of any amount during the past 12 months.      

This activity is supported by an educational grant from Lilly. For further information concerning Lilly grant funding visit

There is no fee for this educational activity.

This activity is provided by

AXIS 1424b

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 ACPE
  • 1.00 ANCC

Accreditation Period

Course opens: 
Course expires: 


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